About Hereditary Angioedema
Hereditary angioedema (HAE) is a rare autoimmunological disease that is caused by
a genetic defect and can be fatal if not treated appropriately.
Learn about 3 types of HAE, a debilitating, multisystem inherited disease caused
by low or dysfunctional levels of plasma protein complement-1 esterase inhibitor
HAE is characterized by acute, recurrent attacks of localized edema. Learn 8 simple
questions to help with diagnosis.
HAE is a rare disorder, accounting for only 2% of clinical angioedema cases. According
to the US Hereditary Angioedema Association (HAEA), epidemiologic studies place
the worldwide incidence of HAE at approximately 1 in 10,000 to 50,000 persons. 9
Low levels of functional C1-INH in plasma lead to unregulated activation of the
complement, contact and fibrinolytic systems and result in angioedema.