About Hereditary Angioedema
Hereditary angioedema (HAE) is a rare autoimmunological disease that is caused by
a genetic defect and can be fatal if not treated appropriately.
Learn about 3 types of HAE, a debilitating, multisystem inherited disease caused
by low levels of functional plasma protein complement-1 esterase inhibitor (C1-INH).
HAE is characterized by acute, recurrent attacks of localized edema. Learn 8 simple
questions to help with diagnosis.
HAE is a rare disorder, accounting for only 2% of clinical angioedema cases. Worldwide
incidence of HAE is approximately 1 in 30,000 to 50,000 persons.
Low levels of functional C1-INH in plasma lead to unregulated activation of the
complement, contact,
fibrinolytic , and coagulation cascades and result in angioedema.