Etiology and Prevalence

Hereditary angioedema (HAE) is rare, representing a low percentage of clinical angioedema cases. (Most cases of angioedema are caused by medications, such as ACE inhibitors used to treat hypertension.)13 The US Hereditary Angioedema Association puts the incidence of HAE at approximately 1 in 50,000 persons.9

HAE affects all ethnic groups, with no recognizable racial predilection. And as an autosomal dominant inheritable genetic disorder, neither sex predominates.14


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In HAE, low levels of functional plasma C1-INH activate the complement, contact, fibrinolytic [glossary], and coagulation cascades. Read about the pathophysiology of HAE

Quality of life with HAE

Patients feel depression, anxiety, and fear of unpredictable attacks, especially if they lack understanding of HAE. Read about quality of life with HAE