HAE Glossary

Sometimes a word or term used to describe hereditary angioedema (HAE) or its treatment needs to be explained. Use the HAE glossary to find the meanings of terms you don’t understand:

| A-B | | C-E | | F-L | | M-R | | S-Z |
pertaining to the part of the body that lies between the chest and the pelvis and encloses the stomach, intestines, liver, spleen, and pancreas
sharp, rapid onset, short severe course
Angioedema (angioneurotic edema):
recurring episodes of noninflammatory swelling
having to do with a chromosome other than a sex chromosome, normally occurring in pairs in somatic cells and singly in gametes.
Autosomal dominant gene:
a gene from one parent that produces its effect even if the gene from the other parent does not match (eg, HAE occurs when only one gene is abnormal for C1-INH)
Autosomal recessive gene:
a gene that does not produce its effect unless there is an identical gene from the other parent (ie, it takes two matching genes to cause the effect)
threadlike linear strand of DNA and associated proteins in the nucleus of animal and plant cells that carries the genes and functions in the transmission of hereditary information
Complement 1 esterase inhibitor (C1-INH):
a protein that helps to regulate the immune system
an accumulation of an excessive amount of watery fluid in cells, tissues, or serous cavities
a sperm or an egg
transmitted or capable of being transmitted genetically from parent to offspring
Hereditary angioedema (HAE):
manifested by recurring episodes of edema of the skin or mucous membranes of the organs, and is caused by the poor functioning or lack of a protein called C1 esterase inhibitor (C1-INH)
a group of enzymes that covert kininogen to bradykinin which promotes vasodilation and edema
affecting or near the larynx (voice box)
Pitting (pitting edema):
formation of well-defined, relatively deep depressions skin over an area of excess fluid accumulation
clear, yellowish fluid portion of blood
symptoms indicating the onset of an attack
Prophylaxis, prophylactic:
treatment designed to prevent or minimize symptoms or attacks
characteristic of the body
an incision through the neck into the windpipe that is made when the upper airway is blocked

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