HAE Glossary

Sometimes a word or term used to describe hereditary angioedema (HAE) or its treatment needs to be explained. Use the HAE glossary to find the meanings of terms you don’t understand:

| A-B | | C-E | | F-L | | M-R | | S-Z |
Abdominal:
pertaining to the part of the body that lies between the chest and the pelvis and encloses the stomach, intestines, liver, spleen, and pancreas
Acute:
sharp, rapid onset, short severe course
Angioedema (angioneurotic edema):
recurring episodes of noninflammatory swelling
Autosomal:
having to do with a chromosome other than a sex chromosome, normally occurring in pairs in somatic cells and singly in gametes.
Autosomal dominant gene:
a gene from one parent that produces its effect even if the gene from the other parent does not match (eg, HAE occurs when only one gene is abnormal for C1-INH)
Autosomal recessive gene:
a gene that does not produce its effect unless there is an identical gene from the other parent (ie, it takes two matching genes to cause the effect)
Chromosome:
threadlike linear strand of DNA and associated proteins in the nucleus of animal and plant cells that carries the genes and functions in the transmission of hereditary information
Complement 1 esterase inhibitor (C1-INH):
a protein that helps to regulate the immune system
Edema:
an accumulation of an excessive amount of watery fluid in cells, tissues, or serous cavities
Gamete:
a sperm or an egg
Hereditary:
transmitted or capable of being transmitted genetically from parent to offspring
Hereditary angioedema (HAE):
manifested by recurring episodes of edema of the skin or mucous membranes of the organs, and is caused by the poor functioning or lack of a protein called C1 esterase inhibitor (C1-INH)
Kallikrein:
a group of enzymes that covert kininogen to bradykinin which promotes vasodilation and edema
Laryngeal:
affecting or near the larynx (voice box)
Pitting (pitting edema):
formation of well-defined, relatively deep depressions skin over an area of excess fluid accumulation
Plasma:
clear, yellowish fluid portion of blood
Prodromal:
symptoms indicating the onset of an attack
Prophylaxis, prophylactic:
treatment designed to prevent or minimize symptoms or attacks
Somatic:
characteristic of the body
Tracheostomy:
an incision through the neck into the windpipe that is made when the upper airway is blocked

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Questions on understanding HAE

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